Insilico Modelling of the Integrative Pathway of Carcinoma by Hpv E6 Protein–protein Interaction

The Human papillomavirus (HPV) E6 protein is one of the oncoproteins encoded by the virus. Inorder to understand the mechanism by which E6 interacts with the host cellular proteins to trigger the cascade of cancer cell transformation. STRING (Search Tool for the Retrieval of Interacting Genes/Proteins) is a biological database has been used to model the pathway of the proteinprotein interaction and how intimately they associate to contribute to the malignancy of the HPV transformed cells. SIPA1L1, E6AP and E6BP three individual annotated pathways enable to construct a putative pathway using their annotations and in literature review. The E6 cellular target has important implications for the development of effective cancer therapeutic strategies.